Testosterone and Cardiovascular Risk: Debunking the Fallacy of Hypertension and Thrombosis
By Mike Mahler
Mark L. Gordon, MD Neuroendocrinology and Integrative Physiology Preface The hypothesis that testosterone replacement therapy (TRT) induces hypertension or heightens thrombotic risk has persisted for decades, often influencing clinical decision-making and public perception. Yet, accumulating evidence from rigorous, peer-reviewed studies—including randomized controlled trials, large cohort analyses, and meta-analyses—has largely debunked this association when TRT is …