DHEA – The Ultimate Stress Management & Longevity Hormone

Attention! USA orders only! No orders to Canada or anywhere outside the USA will be processed 

Dehydroepiandrosterone (DHEA) is one of the most vital hormones your body produces. Known as the ultimate stress management hormone, DHEA plays a crucial role in balancing the negative effects of excess cortisol, the body’s primary stress hormone.

Maintaining optimal DHEA levels is essential for:

• Healthy adrenal function and resilience to stress

• Strong immune system support

• Improved insulin sensitivity and blood sugar control

• Better sleep and recovery

• Bone density and joint health

• Protecting testosterone levels from cortisol’s damaging effects

Over your lifetime, you will release more DHEA than any other hormone, with levels up to 20x higher than other hormones in the bloodstream. Yet, as you age or face chronic stress, DHEA production naturally declines. This drop accelerates aging, weakens your immune system, increases body fat, and disrupts mood, sleep, and sexual health.

The Cortisol–DHEA Connection

Cortisol and DHEA work like a seesaw — when one is high, the other is low.

• High cortisol = low DHEA → fatigue, stubborn belly fat, poor sleep, anxiety, and suppressed testosterone.

• Optimal DHEA = balanced cortisol → improved mood, energy, sex drive, and muscle preservation.

Unfortunately, today’s high-stress lifestyles often lead to chronically elevated cortisol.
This vicious cycle causes you to:

• Wake up tired, feel drained all day, then get a “second wind” at night (wired but exhausted).

• Rely on caffeine, which spikes cortisol even higher.

• Struggle with stubborn belly fat and declining hormones.

DHEA supplementation helps restore balance, lowering cortisol’s impact while supporting your body’s natural anabolic (muscle-building, restorative) processes.

DHEA Protects Testosterone

DHEA is often called “testosterone’s big brother.”
When DHEA levels are optimal, testosterone remains strong and resilient. When DHEA drops, cortisol takes over, leading to plummeting testosterone, loss of muscle, and reduced vitality.

Important Note for Men:
DHEA itself is not a direct testosterone booster. It’s several steps away in the hormonal pathway. In men — especially those carrying extra body fat — supplemental DHEA can convert into estrogen rather than testosterone.

That’s why pairing DHEA with an estrogen blocker such as EC is highly recommended to prevent excess aromatization (conversion into estrogen).

For women, however, DHEA can have a more direct impact. Since a woman’s adrenals are a primary source of testosterone, DHEA supplementation can help restore healthy levels — improving mood, energy, and sex drive.

Caution: Too high a dose may lead to side effects such as acne or unwanted hair growth.

Clinically Proven Benefits of Optimal DHEA Levels

Research from Life Extension Magazine and other clinical studies shows that maintaining or restoring optimal DHEA levels (via natural support or supplementation in the 15mg–50mg range) provides powerful benefits:

• Fat Loss:

  • Reduces visceral (belly) fat and subcutaneous fat under the skin.

• Metabolic Health:

  • Improves insulin sensitivity by up to 30%.

  • Raises protective HDL by nearly 12%, lowers LDL by 11%, and reduces triglycerides by almost 20%.

• Hormonal Balance:

  • Boosts IGF-1 (a key growth factor for blood sugar control and muscle health).

  • Enhances growth hormone levels by up to 20% when taken at night.

• Physical & Psychological Well-being:

  • Men: 67% improvement in mood, energy, and vitality.

  • Women: 84% improvement in overall well-being.

• Longevity & Heart Health:

  • Men with the lowest DHEA levels are 67% more likely to die from a heart attack.

  • Low DHEA increases the risk of death from any cause by 54%.

• Cognitive Support:

  • Higher DHEA correlates with sharper memory, better focus, and lower anxiety.

  • Low levels are linked to burnout, depression, and chronic fatigue.

Signs of Low DHEA

You may have suboptimal DHEA levels if you experience:

• Constant fatigue or burnout

• Stubborn belly fat or cellulite

• Low sex drive (especially in women)

• Dry skin, dry eyes, thinning hair

• Poor recovery from workouts or injuries

• Mood swings, anxiety, or depression

• Poor hair growth in the armpits or pubic area

Optimal DHEA Blood Ranges

According to Dr. Mark Gordon, a leading hormone optimization expert, keeping DHEA-S near 500 µg/dL is ideal for both men and women, with minimal risk of side effects.

Why Supplementing DHEA Matters

While you can support DHEA naturally through sleep, stress management, and nutrition, supplementation offers a direct and effective way to restore balance — especially as production declines with age or chronic stress.

Recommended approach:

• Men: Combine DHEA with an estrogen blocker like EC to prevent excess conversion to estrogen.

• Women: Start with a low dose and monitor for changes in mood, energy, and libido.

By optimizing DHEA, you’re not just addressing one hormone — you’re setting the foundation for a healthier, stronger, and more resilient body and mind.

TWIST 25 DHEA FAQ

What is Twist 25?

Twist 25 cream is the highest quality DHEA cream possible, made with select pharmaceutical-grade ingredients in a carefully engineered cream base. The present formulation of Twist 25 is the result of years of testing and refinement.

What is DHEA?

DHEA is a pro-hormone – a natural building block for hormones our bodies make. After age 25, we make about 2% less DHEA per year. Use Twist 25 to maintain youthful DHEA levels after age 35.

What makes Twist 25 better than other DHEA products?

The cream is the secret! Medical research shows that most DHEA metabolism occurs in the skin.* Twist 25 is a bioidentical DHEA cream that is absorbed into the skin. “Bioidentical” means that the DHEA in Twist 25 is the same molecular structure as is produced in humans.

Why is cream better?

DHEA as cream is far more effective than oral DHEA because most DHEA is metabolized by the body in the skin. When taken as a pill, DHEA is destroyed by the “first-pass effect” of the liver. The liver filters out most DHEA before it can do any good; what does get into the bloodstream is DHEA-S (DHEA sulfate).

Where does the DHEA for Twist 25 come from?

The DHEA in Twist 25 is produced from natural plant sources. Every batch of cream is tested by third-party laboratories to ensure proper mix and strength. Paraben-free. No soy. No cyclodextrins.

How is it used?

Apply 1-2 pump presses morning and evening every day. Rub in completely on thin hairless skin such as between the inner arm and abdomen, face, neck, or inner thighs. Each full pump press contains 25 mg of bioidentical DHEA.

The dispenser is not working. I have tried pumping it dozens of times to no avail

How long does one bottle last? 

For most users, one month of using one pump 2x per day.

When will I notice a difference?

Many subtle benefits are easy to feel within a few weeks.

Can Twist 25 be used with your other supplements? 

Yes, it can be used with any of my products. In particular, it stacks well with ASTB as increased DHEA levels support increased total and free testosterone levels for a greater sex drive, mood, and stress management. DHEA can convert to estrogen, so taking 1-2 caps of EC while you use DHEA is a good idea to avoid excessive conversion to estrogen. Especially if you carry excess body fat in the stomach and lower body.*

Do you offer a satisfaction guarantee? 

Not for Twist 25 DHEA purchases. This product is not part of the Aggressive strength line and, as a result, does not come with the 30-day money-back guarantee. Don’t bother taking this product if you have not determined that you have low DHEA levels and could benefit from supplementation. I am carrying this product because I have recommended it to my customers for years and want to make it more convenient for them to purchase it along with my other products.

How long does it take for delivery? 

All orders placed from Sunday to Thursday are shipped within twenty-four hours. USA orders are shipped by USPS Priority Mail and delivered on average within five business days. Orders to Canada are delivered within 7-10 days on average. Orders sent to Europe and Australia generally take two weeks, and orders sent to Asia take 3-4 weeks. Delays can result from customs taking longer to clear orders.

Does your company support any causes or charities?

Yes, I am a strong financial supporter of many charities, including Project Child Save to help save kids from human trafficking, The Warrior Angels Foundation to help soldiers with PTSD due to traumatic brain injuries; Voice For The Animals,  to help homeless animals, and animal rights legislation, and No Dogs Left Behind to help rescue animals from the horrific dog meat trade. When you support my company, you indirectly support all of these fantastic organizations and many others.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.