Systemic enzymes are increasingly gaining attention in the world of health and wellness for their wide-ranging benefits that go far beyond digestion. Unlike digestive enzymes, which primarily assist in breaking down food in the gastrointestinal tract, systemic enzymes operate throughout the body to support various physiological processes—making them a powerful tool for inflammation control, tissue repair, immune support, and overall vitality.
What Are Systemic Enzymes?
Systemic (or proteolytic) enzymes are taken on an empty stomach so they can bypass the digestive system and enter the bloodstream, where they perform regulatory and restorative functions. Common systemic enzymes include:
- Serrapeptase
- Nattokinase
- Bromelain
- Papain
- Trypsin and Chymotrypsin
- Lumbrokinase
These enzymes help break down proteins in the blood that can contribute to inflammation, scar tissue, and excess fibrin—an insoluble protein involved in blood clotting.
1. Anti-Inflammatory Action
One of the most well-documented benefits of systemic enzymes is their ability to reduce inflammation. Chronic inflammation is a root cause of many diseases, including arthritis, heart disease, and autoimmune disorders. Enzymes like serrapeptase and bromelain help degrade pro-inflammatory proteins and reduce swelling and pain, offering a natural alternative to NSAIDs without the gastrointestinal side effects.
2. Supports Joint Health and Mobility
Because of their anti-inflammatory and fibrin-reducing effects, systemic enzymes are often used to manage joint pain, stiffness, and reduced range of motion. Athletes and aging individuals alike may benefit from the enzymes’ ability to support tissue recovery and reduce discomfort from overuse or wear and tear.
3. Scar Tissue and Fibrosis Reduction
Systemic enzymes can help dissolve excess fibrin, a protein that contributes to the formation of scar tissue, adhesions, and fibrosis (e.g., pulmonary or liver fibrosis). This can be beneficial for:
- Post-surgical recovery
- Cystic fibrosis support
- Uterine fibroids
- Peyronie’s disease
4. Cardiovascular Health
Some enzymes, such as nattokinase and lumbrokinase, are known to help break down fibrin and blood clots, supporting healthy circulation and reducing the risk of stroke, deep vein thrombosis (DVT), and other clot-related conditions. Nattokinase, derived from natto (fermented soy), has been particularly noted for its blood-thinning properties.
5. Immune System Modulation
Systemic enzymes help modulate immune function, supporting both underactive and overactive immune responses. By reducing the “protein debris” from inflammation and infection, enzymes lighten the immune system’s load, potentially improving resistance to illness and speeding recovery.
6. Improved Detoxification
Enzymes help clear waste and dead tissue from the blood, contributing to a more efficient detoxification process. This systemic clean-up may also support liver function and overall cellular health.
7. Respiratory Health
By reducing mucus thickness and inflammation, systemic enzymes can benefit individuals with chronic respiratory conditions such as:
- Chronic bronchitis
- Asthma
- Sinusitis
Serrapeptase, in particular, has mucolytic (mucus-dissolving) effects that help improve breathing and reduce sinus congestion.
Usage and Safety
To be effective, systemic enzymes must be taken on an empty stomach—typically 30–60 minutes before eating or 2–3 hours after a meal—so they can enter the bloodstream rather than aid in digestion.
While systemic enzymes are generally safe, they may interact with blood thinners and other medications. People with bleeding disorders or those scheduled for surgery should consult a healthcare provider before using them.
Conclusion
Systemic enzymes are a promising and natural way to support overall health by addressing inflammation, scar tissue, immune imbalance, and circulatory concerns. Whether you’re an athlete, dealing with chronic pain, or simply seeking to age more gracefully, these enzymes offer a holistic tool for internal balance and rejuvenation.
| Enzyme | Known For |
|---|---|
| Serrapeptase | Anti-inflammatory, scar tissue breakdown |
| Nattokinase | Cardiovascular support, fibrin breakdown |
| Bromelain | Anti-inflammatory, protein-digesting |
| Papain | Anti-inflammatory, digestive and systemic |
| Protease | General protein breakdown, immune support |
⚠️ Tips & Precautions
- Take on an empty stomach (30–60 min before meals or 2+ hours after).
- Avoid with blood thinners unless supervised—especially nattokinase and serrapeptase.
- Start slow: Some people experience mild detox-like symptoms when first starting.
Use Restorezyme now to address aches and pains, lower inflammation, decrease recovery time, and increase health and vitality!*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
